Insights into Uromodulin and Blood Pressure

Overview

Journal Curr Hypertens Rep

Specialty Cardiology & Vascular Diseases

Date 2024 Sep 11

PMID 39259220

Authors

Manshi Zhou

Sheon Mary

Christian Delles

Sandosh Padmanabhan

Delyth Graham

Martin W McBride

Anna F Dominiczak

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: We review the role of uromodulin, a protein exclusively expressed in the kidney, in blood pressure regulation and hypertension.

Recent Findings: The last few years have seen a shift of focus from genetic association to mendelian randomisation and uromodulin-salt interaction studies, thus confirming the causal role of uromodulin in blood pressure regulation and hypertension. This work has been complemented by phenome-wide association studies in a wider range of ethnicities. Important recent molecular work elucidated uromodulin trafficking and secretion and provided more insights into the pathophysiological roles of circulating and urinary uromodulin. Uromodulin has a causal role in blood pressure regulation and hypertensin. Recent studies show utility of the uromodulin as a biomarker and a possible precision medicine application based on genetically determined differential responses to loop diuretics.

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