Dynamic Analysis of the Relationship Between Systemic Lupus Erythematosus Disease Activity and Psychosocial Support

Overview

Journal Front Psychol

Date 2024 Aug 29

PMID 39205979

Authors

Miao Lu

Min Liu

Kuijun Zhan

Yutong Chen

Xide Liu

Affiliations

Soon will be listed here.

Abstract

Background: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease that significantly affects both the physical and mental health of patients. Psychosocial support systems play a crucial role in managing chronic diseases, yet their specific impact on the disease activity of SLE patients remains unclear. This study aims to explore the dynamic relationship between disease activity in SLE patients and various types of psychosocial support systems.

Methods: We conducted a retrospective longitudinal observational study, including 150 SLE patients who received treatment at our hospital from January 2022 to January 2023. Emotional support, tangible support, social interaction support, and informational support were assessed using the revised Social Support Rating Scale. Disease activity was quantified using the European Consensus Lupus Activity Measurement. The relationship between psychosocial support and disease activity was analyzed using Spearman's rank correlation coefficient and multiple linear regression models, with Bootstrap resampling employed to test the robustness of the results.

Results: We found a significant negative correlation between psychosocial support and SLE disease activity, with emotional support, social interaction support, and informational support showing stronger negative correlations. Multiple regression analysis revealed that the inhibitory effects of emotional support, social interaction support, and informational support on disease activity increased over time. Although the impact of tangible support was not statistically significant, it gradually became more apparent over time.

Conclusion: Our findings indicate a significant negative correlation between psychosocial support and SLE disease activity, particularly with emotional support, social interaction support, and informational support. Over time, the impact of tangible support also becomes evident. These findings provide important references for the comprehensive treatment and management of SLE patients. However, due to the observational nature of the study, the causality of this relationship requires further exploration.

References

Piga M, Arnaud L . The Main Challenges in Systemic Lupus Erythematosus: Where Do We Stand?. J Clin Med. 2021; 10(2). PMC: 7827672. DOI: 10.3390/jcm10020243. View

Woloshin S, Schwartz L, Tosteson A, Chang C, Wright B, Plohman J . Perceived adequacy of tangible social support and health outcomes in patients with coronary artery disease. J Gen Intern Med. 1997; 12(10):613-8. PMC: 1497172. DOI: 10.1046/j.1525-1497.1997.07121.x. View

Mazzoni D, Cicognani E . Positive and problematic support, stress and quality of life in patients with systemic lupus erythematosus. Anxiety Stress Coping. 2015; 29(5):542-51. DOI: 10.1080/10615806.2015.1134785. View

Chaigne B, Chizzolini C, Perneger T, Trendelenburg M, Huynh-Do U, Dayer E . Impact of disease activity on health-related quality of life in systemic lupus erythematosus - a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS). BMC Immunol. 2017; 18(1):17. PMC: 5371245. DOI: 10.1186/s12865-017-0200-5. View

Chang A, Winquist N, Wescott A, Lattie E, Graham A . Systematic review of digital and non-digital non-pharmacological interventions that target quality of life and psychological outcomes in adults with systemic lupus erythematosus. Lupus. 2021; 30(7):1058-1077. PMC: 8122052. DOI: 10.1177/09612033211005085. View

Pan Q, Chen X, Liao S, Chen X, Zhao C, Xu Y . Updated advances of linking psychosocial factors and sex hormones with systemic lupus erythematosus susceptibility and development. PeerJ. 2019; 7:e7179. PMC: 6598654. DOI: 10.7717/peerj.7179. View

Hurtado-de-Mendoza A, Gonzales F, Song M, Holmes E, Graves K, Retnam R . Association between aspects of social support and health-related quality of life domains among African American and White breast cancer survivors. J Cancer Surviv. 2021; 16(6):1379-1389. PMC: 10166003. DOI: 10.1007/s11764-021-01119-2. View

Cui X, Zhou X, Ma L, Sun T, Bishop L, Gardiner F . A nurse-led structured education program improves self-management skills and reduces hospital readmissions in patients with chronic heart failure: a randomized and controlled trial in China. Rural Remote Health. 2019; 19(2):5270. DOI: 10.22605/RRH5270. View

Yu D, Lee D, Woo J . Psychometric testing of the Chinese version of the medical outcomes study social support survey (MOS-SSS-C). Res Nurs Health. 2004; 27(2):135-43. DOI: 10.1002/nur.20008. View

10.

Zhang W, Tang Z, Shi Y, Ji L, Chen X, Chen Y . Association Between Gamma-Glutamyl Transferase, Total Bilirubin and Systemic Lupus Erythematosus in Chinese Women. Front Immunol. 2021; 12:682400. PMC: 8277571. DOI: 10.3389/fimmu.2021.682400. View

11.

Wang Y, Sun H, Liu Y, Gong X, Xu Y, Zong Q . Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls. Qual Life Res. 2023; 33(1):207-218. DOI: 10.1007/s11136-023-03516-9. View

12.

Carr F, Nicassio P, Ishimori M, Moldovan I, Katsaros E, Torralba K . Depression predicts self-reported disease activity in systemic lupus erythematosus. Lupus. 2010; 20(1):80-4. DOI: 10.1177/0961203310378672. View

13.

Arabyat R, Raisch D . Relationships Between Social/Emotional Support and Quality of Life, Depression and Disability in Patients With Chronic Obstructive Pulmonary Disease: An Analysis Based on Propensity Score Matching. Ann Behav Med. 2019; 53(10):918-927. DOI: 10.1093/abm/kaz002. View

14.

Zeng T, Jiang L, Zhang K, Wu M, Zhu Z, Hu Z . The influence of sense of coherence on psychological birth trauma: a parallel mediation model based on health Salutogenesis theory. Front Psychol. 2024; 14:1320132. PMC: 10797134. DOI: 10.3389/fpsyg.2023.1320132. View

15.

Jump R, Robinson M, Armstrong A, Barnes E, Kilbourn K, Richards H . Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support. J Rheumatol. 2005; 32(9):1699-705. View

16.

Chen J, Liao S, Pang W, Guo F, Yang L, Liu H . Life factors acting on systemic lupus erythematosus. Front Immunol. 2022; 13:986239. PMC: 9521426. DOI: 10.3389/fimmu.2022.986239. View

17.

Wanberg L, Pearson D . Evaluating the Disease-Related Experiences of TikTok Users With Lupus Erythematosus: Qualitative and Content Analysis. JMIR Infodemiology. 2024; 4:e51211. PMC: 11063877. DOI: 10.2196/51211. View

18.

Walburn J, Anderson R, Morgan M . Forms, interactions, and responses to social support: A qualitative study of support and adherence to photoprotection amongst patients with Xeroderma Pigmentosum. Br J Health Psychol. 2019; 25(1):89-106. PMC: 7004138. DOI: 10.1111/bjhp.12396. View

19.

Barraclough M, Howe A, Soberanis A, Kakvan M, Chattu V, Bani-Fatemi A . The Effects of Systemic Lupus-Related Cognitive Impairments on Activities of Daily Living and Life Role Participation: A Qualitative Framework Study. ACR Open Rheumatol. 2023; 6(1):21-30. PMC: 10789303. DOI: 10.1002/acr2.11624. View

20.

Tsai C, Shen C, Liu C, Hsieh S, Liao H, Li K . Aberrant Non-Coding RNA Expression in Patients with Systemic Lupus Erythematosus: Consequences for Immune Dysfunctions and Tissue Damage. Biomolecules. 2020; 10(12). PMC: 7762297. DOI: 10.3390/biom10121641. View