Aberrant Non-Coding RNA Expression in Patients with Systemic Lupus Erythematosus: Consequences for Immune Dysfunctions and Tissue Damage

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Dec 9

PMID 33291347

Citations 21

Authors

Chang-Youh Tsai

Chieh-Yu Shen

Chih-Wei Liu

Song-Chou Hsieh

Hsien-Tzung Liao

Ko-Jen Li

Cheng-Shiun Lu

Hui-Ting Lee

Cheng-Sung Lin

Cheng-Han Wu

Yu-Min Kuo

Chia-Li Yu

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with heterogeneous clinical manifestations. A diverse innate and adaptive immune dysregulation is involved in the immunopathogenesis of SLE. The dysregulation of immune-related cells may derive from the intricate interactions among genetic, epigenetic, environmental, and immunological factors. Of these contributing factors, non-coding RNAs (ncRNAs), including microRNAs (miRNAs, miRs), and long non-coding RNAs (lncRNAs) play critical roles in the post-transcriptional mRNA expression of cytokines, chemokines, and growth factors, which are essential for immune modulation. In the present review, we emphasize the roles of ncRNA expression in the immune-related cells and cell-free plasma, urine, and tissues contributing to the immunopathogenesis and tissue damage in SLE. In addition, the circular RNAs (circRNA) and their post-translational regulation of protein synthesis in SLE are also briefly described. We wish these critical reviews would be useful in the search for biomarkers/biosignatures and novel therapeutic strategies for SLE patients in the future.

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References

Brown E, Edberg J, Kimberly R . Fc receptor genes and the systemic lupus erythematosus diathesis. Autoimmunity. 2007; 40(8):567-81. DOI: 10.1080/08916930701763710. View

Henriques A, Teixeira L, Ines L, Carvalheiro T, Goncalves A, Martinho A . NK cells dysfunction in systemic lupus erythematosus: relation to disease activity. Clin Rheumatol. 2013; 32(6):805-13. DOI: 10.1007/s10067-013-2176-8. View

Moulton V, Tsokos G . T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity. J Clin Invest. 2015; 125(6):2220-7. PMC: 4497749. DOI: 10.1172/JCI78087. View

Wang G, Tam L, Kwan B, Li E, Chow K, Luk C . Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus. Clin Rheumatol. 2011; 31(3):435-40. DOI: 10.1007/s10067-011-1857-4. View

Zhang Y, Zhao M, Sawalha A, Richardson B, Lu Q . Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun. 2013; 41:92-9. DOI: 10.1016/j.jaut.2013.01.005. View

Zhang Z, Song L, Maurer K, Petri M, Sullivan K . Global H4 acetylation analysis by ChIP-chip in systemic lupus erythematosus monocytes. Genes Immun. 2009; 11(2):124-33. PMC: 2832080. DOI: 10.1038/gene.2009.66. View

Ma J, Zhao N, Du L, Wang Y . Downregulation of lncRNA NEAT1 inhibits mouse mesangial cell proliferation, fibrosis, and inflammation but promotes apoptosis in diabetic nephropathy. Int J Clin Exp Pathol. 2020; 12(4):1174-1183. PMC: 6947069. View

Zavala-Cerna M, Martinez-Garcia E, Torres-Bugarin O, Rubio-Jurado B, Riebeling C, Nava A . The clinical significance of posttranslational modification of autoantigens. Clin Rev Allergy Immunol. 2014; 47(1):73-90. DOI: 10.1007/s12016-014-8424-0. View

Wei J, Huang K, Yang C, Kang C . Non-coding RNAs as regulators in epigenetics (Review). Oncol Rep. 2016; 37(1):3-9. DOI: 10.3892/or.2016.5236. View

10.

Leiss H, Salzberger W, Jacobs B, Gessl I, Kozakowski N, Bluml S . MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus. PLoS One. 2017; 12(7):e0181015. PMC: 5515414. DOI: 10.1371/journal.pone.0181015. View

11.

Pan L, Lu M, Wang J, Xu M, Yang S . Immunological pathogenesis and treatment of systemic lupus erythematosus. World J Pediatr. 2019; 16(1):19-30. PMC: 7040062. DOI: 10.1007/s12519-019-00229-3. View

12.

Terzoglou A, Routsias J, Avrameas S, Moutsopoulos H, Tzioufas A . Preferential recognition of the phosphorylated major linear B-cell epitope of La/SSB 349-368 aa by anti-La/SSB autoantibodies from patients with systemic autoimmune diseases. Clin Exp Immunol. 2006; 144(3):432-9. PMC: 1941980. DOI: 10.1111/j.1365-2249.2006.03088.x. View

13.

Liu Y, Lightfoot Y, Seto N, Carmona-Rivera C, Moore E, Goel R . Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018; 3(23). PMC: 6328098. DOI: 10.1172/jci.insight.124729. View

14.

Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z . Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. J Transl Med. 2016; 14(1):225. PMC: 4964270. DOI: 10.1186/s12967-016-0977-7. View

15.

Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z . Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark. 2015; 16(1):161-9. DOI: 10.3233/CBM-150552. View

16.

Rose T, Dorner T . Drivers of the immunopathogenesis in systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2017; 31(3):321-333. DOI: 10.1016/j.berh.2017.09.007. View

17.

Lu M, Lai N, Chen H, Yu H, Huang K, Tung C . Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis. Clin Exp Immunol. 2012; 171(1):91-9. PMC: 3530100. DOI: 10.1111/j.1365-2249.2012.04676.x. View

18.

Hedrich C . Mechanistic aspects of epigenetic dysregulation in SLE. Clin Immunol. 2018; 196:3-11. DOI: 10.1016/j.clim.2018.02.002. View

19.

Kim B, Jung J, Jeon J, Kim H, Suh C . Circulating hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p may be novel biomarkers in systemic lupus erythematosus. HLA. 2016; 88(4):187-93. DOI: 10.1111/tan.12874. View

20.

Lu M, Yu C, Chen H, Yu H, Huang H, Lai N . Aberrant T cell expression of Ca2+ influx-regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis. Rheumatology (Oxford). 2014; 54(2):343-8. DOI: 10.1093/rheumatology/keu322. View