Life Factors Acting on Systemic Lupus Erythematosus

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Oct 3

PMID 36189303

Authors

Jiaxuan Chen

Shuzhen Liao

Wanxian Pang

Fengbiao Guo

Lawei Yang

Hua-Feng Liu

Qingjun Pan

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. Currently, in the search for the mechanisms of SLE pathogenesis, the association of lifestyle factors such as diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption with SLE susceptibility has been systematically investigated. The cellular and molecular mechanisms mediating lifestyle effects on SLE occurrence, including interactions between genetic risk loci and environment, epigenetic changes, immune dysfunction, hyper-inflammatory response, and cytotoxicity, have been proposed. In the present review of the reports published in reputable peer-reviewed journals and government websites, we consider the current knowledge about the relationships between lifestyle factors and SLE incidence and outline directions of future research in this area. Formulation of practical measures with regard to the lifestyle in the future will benefit SLE patients and may provide potential therapy strategies.

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