Parasites of the Liver: A Global Problem?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2024 Aug 28

PMID 39193571

Authors

Vladislav V Tsukanov

Alexander V Vasyutin

Julia L Tonkikh

Affiliations

Soon will be listed here.

Abstract

Parasitic liver diseases can be caused by trematodes, cestodes, nematodes, and protozoa. This pathology is significant because millions of people in different parts of the world have liver parasites, which can manifest themselves in the development of inflammation, liver cysts, cholecystitis, cholelithiasis, pancreatitis and liver cirrhosis that are often threatening their lives. The International Agency for Research on Cancer considers three species of trematodes, , and , to be carcinogens. Complex modern examination methods, in some cases including extensive screening of large populations, are required for diagnosing liver parasites. Treatment of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic measures. There is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.

Citing Articles

Liver parasites: A global endemic and journey from infestation to intervention.

Shahid Y, Emman B, Abid S World J Gastroenterol. 2025; 31(1):101360.

PMID: 39777245 PMC: 11684182. DOI: 10.3748/wjg.v31.i1.101360.

References

Zhao T, Feng Y, Doanh P, Sayasone S, Khieu V, Nithikathkul C . Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia. Elife. 2021; 10. PMC: 7870142. DOI: 10.7554/eLife.59755. View

Vellere I, Mangano V, Cagno M, Gobbi F, Ragusa A, Bartoloni A . Imported human Schistosoma japonicum: A report on two cases in Filipino migrants present in Italy and a systematic review of literature. Travel Med Infect Dis. 2019; 36:101496. DOI: 10.1016/j.tmaid.2019.101496. View

Mas-Coma S, Bargues M, Valero M . Fascioliasis and other plant-borne trematode zoonoses. Int J Parasitol. 2005; 35(11-12):1255-78. DOI: 10.1016/j.ijpara.2005.07.010. View

Haseeb A, M El-Shazly A, Arafa M, Morsy A . A review on fascioliasis in Egypt. J Egypt Soc Parasitol. 2002; 32(1):317-54. View

Santos L, Santos J, Gouveia M, Bernardo C, Lopes C, Rinaldi G . Urogenital Schistosomiasis-History, Pathogenesis, and Bladder Cancer. J Clin Med. 2021; 10(2). PMC: 7826813. DOI: 10.3390/jcm10020205. View

Saijuntha W, Sithithaworn P, Kiatsopit N, Andrews R, Petney T . Liver Flukes: Clonorchis and Opisthorchis. Adv Exp Med Biol. 2019; 1154:139-180. DOI: 10.1007/978-3-030-18616-6_6. View

Ekpanyapong S, Reddy K . Fungal and Parasitic Infections of the Liver. Gastroenterol Clin North Am. 2020; 49(2):379-410. DOI: 10.1016/j.gtc.2020.01.009. View

Xia J, Jiang S, Peng H . Association between Liver Fluke Infection and Hepatobiliary Pathological Changes: A Systematic Review and Meta-Analysis. PLoS One. 2015; 10(7):e0132673. PMC: 4506038. DOI: 10.1371/journal.pone.0132673. View

Peters L, Burkert S, Gruner B . Parasites of the liver - epidemiology, diagnosis and clinical management in the European context. J Hepatol. 2021; 75(1):202-218. DOI: 10.1016/j.jhep.2021.02.015. View

10.

Tan S, Machrumnizar M . Fish and Food-Fatale: Food-borne Trematode and Cholangiocarcinoma. Helminthologia. 2024; 60(4):287-299. PMC: 10787637. DOI: 10.2478/helm-2023-0036. View

11.

Mazigo H, Nuwaha F, Dunne D, Kaatano G, Angelo T, Kepha S . Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania: A Cross-Sectional Exploratory Study. Korean J Parasitol. 2017; 55(5):533-540. PMC: 5678472. DOI: 10.3347/kjp.2017.55.5.533. View

12.

Wiegand R, Fleming F, de Vlas S, Odiere M, Kinunghi S, King C . Defining elimination as a public health problem for schistosomiasis control programmes: beyond prevalence of heavy-intensity infections. Lancet Glob Health. 2022; 10(9):e1355-e1359. PMC: 10184143. DOI: 10.1016/S2214-109X(22)00287-X. View

13.

Tidman R, Kanankege K, Bangert M, Abela-Ridder B . Global prevalence of 4 neglected foodborne trematodes targeted for control by WHO: A scoping review to highlight the gaps. PLoS Negl Trop Dis. 2023; 17(3):e0011073. PMC: 9980766. DOI: 10.1371/journal.pntd.0011073. View

14.

Charoensuk L, Subrungruang I, Mungthin M, Pinlaor S, Suwannahitatorn P . Comparison of stool examination techniques to detect Opisthorchis viverrini in low intensity infection. Acta Trop. 2018; 191:13-16. DOI: 10.1016/j.actatropica.2018.12.018. View

15.

Piarroux M, Piarroux R, Giorgi R, Knapp J, Bardonnet K, Sudre B . Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients. J Hepatol. 2011; 55(5):1025-33. DOI: 10.1016/j.jhep.2011.02.018. View

16.

Chai J, Jung B . General overview of the current status of human foodborne trematodiasis. Parasitology. 2022; 149(10):1262-1285. PMC: 10090779. DOI: 10.1017/S0031182022000725. View

17.

Qian M, Keiser J, Utzinger J, Zhou X . Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control. Clin Microbiol Rev. 2024; 37(1):e0000923. PMC: 10938900. DOI: 10.1128/cmr.00009-23. View

18.

Deardorff K, Means A, Asbjornsdottir K, Walson J . Strategies to improve treatment coverage in community-based public health programs: A systematic review of the literature. PLoS Negl Trop Dis. 2018; 12(2):e0006211. PMC: 5805161. DOI: 10.1371/journal.pntd.0006211. View

19.

Kura K, Ayabina D, Hollingsworth T, Anderson R . Determining the optimal strategies to achieve elimination of transmission for Schistosoma mansoni. Parasit Vectors. 2022; 15(1):55. PMC: 8842958. DOI: 10.1186/s13071-022-05178-x. View

20.

Zhang Y, Gong Q, Lv Q, Qiu Y, Wang Y, Qiu H . Prevalence of Clonorchis sinensis infection in fish in South-East Asia: A systematic review and meta-analysis. J Fish Dis. 2020; 43(11):1409-1418. DOI: 10.1111/jfd.13245. View