PARP Enzymes and Mono-ADP-ribosylation: Advancing the Connection from Interferon-signalling to Cancer Biology

Overview

Journal Expert Rev Mol Med

Specialty General Medicine

Date 2024 Aug 27

PMID 39189367

Authors

Barbara Morone

Giovanna Grimaldi

Affiliations

Soon will be listed here.

Abstract

ADP-ribosyltransferases of the PARP family encompass a group of enzymes with variegated regulatory functions in cells, ranging from DNA damage repair to the control of cell-cycle progression and immune response. Over the years, this knowledge has led to the use of PARP1/2 inhibitors as mainstay pharmaceutical strategies for the treatment of ovarian, pancreatic, prostate and breast cancers, holding mutations in genes encoding for proteins involved in the DNA repair mechanisms (synthetic lethality). Meanwhile, the last decade has witnessed significant progress in comprehending cellular pathways regulated by mono-ADP-ribosylation, with a huge effort in the development of novel selective compounds to inhibit those PARPs endowed with mono-ADP-ribosylation activity. This review focuses on the progress achieved in the cancer field, delving into most recent findings regarding the role of a subset of enzymes - the interferon-stimulated PARPs - in cancer progression.

Citing Articles

PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response.

Pavithran A, Matarese M, Morone B, Filograna A, Monte M, Dathan N Cell Mol Life Sci. 2025; 82(1):58.

PMID: 39847113 PMC: 11757654. DOI: 10.1007/s00018-025-05586-z.

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