Transcriptional Bursting: from Fundamentals to Novel Insights

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2024 Aug 9

PMID 39119657

Authors

Daniel Hebenstreit

Pradip Karmakar

Affiliations

Soon will be listed here.

Abstract

Transcription occurs as irregular bursts in a very wide range of systems, including numerous different species and many genes within these. In this review, we examine the underlying theories, discuss how these relate to experimental measurements, and explore some of the discrepancies that have emerged among various studies. Finally, we consider more recent works that integrate novel concepts, such as the involvement of biomolecular condensates in enhancer-promoter interactions and their effects on the dynamics of transcriptional bursting.

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