A High-light Therapy Restores the Circadian Clock and Corrects the Pathological Syndrome Generated in Restricted-fed Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2024 Jul 29

PMID 39074282

Authors

Manohar Damara

Nisha Misra

Pierre Chambon

Affiliations

Soon will be listed here.

Abstract

Time-restricted feeding (RF) is known to shift the phasing of gene expression in most primary metabolic tissues, whereas a time misalignment between the suprachiasmatic nucleus circadian clock (SCNCC) and its peripheral CCs (PCC's) is known to induce various pathophysiological conditions, including a metabolic syndrome. We now report that a unique "light therapy," involving different light intensities (T150-T700 lx, T75-T150 lx, and T350-T700 lx), realigns the RF-generated misalignment between the SCNCC and the PCC's. Using such high-light regime, we show that through shifting the SCNCC and its activity, it is possible in a RF and "night-shifted mouse model" to prevent/correct pathophysiologies (e.g., a metabolic syndrome, a loss of memory, cardiovascular abnormalities). Our data indicate that such a "high-light regime" could be used as a unique chronotherapy, for those working on night shifts or suffering from jet-lag, in order to realign their SCNCC and PCC's, thereby preventing the generation of pathophysiological conditions.

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