Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1972 Jun 1

PMID 4556464

Citations 532

Authors

F K Stephan

I Zucker

Affiliations

Soon will be listed here.

Abstract

Bilateral electrolytic lesions in the suprachiasmatic nuclei permanently eliminated nocturnal and circadian rhythms in drinking behavior and locomotor activity of albino rats. The generation of 24-hr behavioral rhythms and the entrainment of these rhythms to the light-dark cycle of environmental illumination may be coordinated by neurons in the suprachiasmatic region of the rat brain. Destruction of the medial preoptic area had no effect on 24-hr drinking rhythms.

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References

Kakolewski J, DEAUX E, Christensen J, Case B . Diurnal patterns in water and food intake and body weight changes in rats with hypothalamic lesions. Am J Physiol. 1971; 221(3):711-8. DOI: 10.1152/ajplegacy.1971.221.3.711. View

Zucker I . Light-dark rhythms in rat eating and drinking behavior. Physiol Behav. 1971; 6(2):115-26. DOI: 10.1016/0031-9384(71)90078-3. View

Stephan F, Zucker I . Rat drinking rhythms: central visual pathways and endocrine factors mediating responsiveness to environmental illumination. Physiol Behav. 1972; 8(2):315-26. DOI: 10.1016/0031-9384(72)90379-4. View