Rejuvenation of Leukocyte Trafficking in Aged Mice Through PEPITEM Intervention

Overview

Journal NPJ Aging

Publisher Springer Nature

Specialty Geriatrics

Date 2024 Jul 18

PMID 39025913

Authors

Sophie J Hopkin

Poppy Nathan

Laleh Pezhman

Jenefa Begum

Julia E Manning

Lauren M Quinn

G Ed Rainger

Helen M McGettrick

Asif J Iqbal

Myriam Chimen

Affiliations

Soon will be listed here.

Abstract

Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on leukocyte migration in ageing. We then analysed whether PEPITEM could modulate leukocyte migration in older adults. We observed a loss of functionality in the PEPITEM pathway, which normally controls leukocyte trafficking in response to inflammation, in older adults and aged mice and show that this can be rescued by supplementation with PEPITEM. Thus, leading to the exciting possibility that PEPITEM supplementation may represent a potential pre-habilitation geroprotective agent to rejuvenate immune functions.

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