Helen M McGettrick
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Explore the profile of Helen M McGettrick including associated specialties, affiliations and a list of published articles.
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70
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1579
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Recent Articles
1.
Ferapontov A, Mellemkjaer A, McGettrick H, Vorup-Jensen T, Kragstrup T, Juul-Madsen K
J Transl Autoimmun
. 2025 Jan;
10:100266.
PMID: 39867459
The family of heterodimeric CD11/CD18 integrins facilitate leukocyte adhesion and migration in a wide range of normal physiologic responses, as well as in the pathology of inflammatory diseases. Soluble CD18...
2.
Saviano A, Apta B, Tull S, Pezhman L, Fatima A, Sevim M, et al.
Pharmacol Res
. 2025 Jan;
213:107624.
PMID: 39855372
PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs). Here, we identify two independently active tripeptide pharmacophores within PEPITEM and engineered peptidomimetics with enhanced...
3.
Neag G, Lewis J, Turner J, Manning J, Dean I, Finlay M, et al.
Commun Biol
. 2024 Oct;
7(1):1296.
PMID: 39394430
Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial...
4.
Hopkin S, Nathan P, Pezhman L, Begum J, Manning J, Quinn L, et al.
NPJ Aging
. 2024 Jul;
10(1):33.
PMID: 39025913
Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on...
5.
Lewis J, Frost K, Neag G, Wahid M, Finlay M, Northall E, et al.
Cell Rep Med
. 2024 Jul;
5(8):101657.
PMID: 38986622
No abstract available.
6.
Manning J, Harris E, Mathieson H, Sorensen L, Luqmani R, McGettrick H, et al.
J Autoimmun
. 2024 May;
147:103260.
PMID: 38797046
Objective: In polymyalgia rheumatica (PMR), glucocorticoids (GCs) relieve pain and stiffness, but fatigue may persist. We aimed to explore the effect of disease, GCs and PMR symptoms in the metabolite...
7.
The Species Effect: Differential Sphingosine-1-Phosphate Responses in the Bone in Human Versus Mouse
Frost K, Lewis J, Jones S, Edwards J, Naylor A, McGettrick H
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791156
The deterioration of osteoblast-led bone formation and the upregulation of osteoclast-regulated bone resorption are the primary causes of bone diseases, including osteoporosis. Numerous circulating factors play a role in bone...
8.
Lewis J, Frost K, Neag G, Wahid M, Finlay M, Northall E, et al.
Cell Rep Med
. 2024 May;
5(5):101574.
PMID: 38776873
The existing suite of therapies for bone diseases largely act to prevent further bone loss but fail to stimulate healthy bone formation and repair. We describe an endogenous osteopeptide (PEPITEM)...
9.
Chidomere C, Wahid M, Kemble S, Chadwick C, Thomas R, Hardy R, et al.
Discov Immunol
. 2024 Apr;
2(1):kyac010.
PMID: 38567064
Inflammatory arthritides such as rheumatoid arthritis are a major cause of disability. Pre-clinical murine models of inflammatory arthritis continue to be invaluable tools with which to identify and validate therapeutic...
10.
Abudu O, Nguyen D, Millward I, Manning J, Wahid M, Lightfoot A, et al.
Biomed Pharmacother
. 2024 Feb;
172:116283.
PMID: 38377735
Background: Galectins (Gal's) are a family of carbohydrate-binding proteins that are known to support the tumour microenvironment through their immunosuppressive activity and ability to promote metastasis. As such they are...