Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-proresolving Medicines

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2014 Sep 14

PMID 25217168

Citations 91

Authors

Hildur H Arnardottir

Jesmond Dalli

Romain A Colas

Masakazu Shinohara

Charles N Serhan

Affiliations

Soon will be listed here.

Abstract

Aging is associated with an overt inflammatory phenotype and physiological decline. Specialized proresolving lipid mediators (SPMs) are endogenous autacoids that actively promote resolution of inflammation. In this study, we investigated resolution of acute inflammation in aging and the roles of SPMs. Using a self-resolving peritonitis and resolution indices coupled with lipid mediator metabololipidomics, we found that aged mice had both delayed resolution and reduced SPMs. The SPM precursor docosahexaenoic acid accelerated resolution via increased SPMs and promoted human monocyte reprogramming. In aged mice, novel nano-proresolving medicines carrying aspirin-triggered resolvins D1 and D3 reduced inflammation by promoting efferocytosis. These findings provide evidence for age-dependent resolution pathways in acute inflammation and novel means to activate resolution.

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