Mechanism and Complex Roles of HSC70/HSPA8 in Viral Entry

Overview

Journal Virus Res

Specialty Microbiology

Date 2024 Jul 11

PMID 38992806

Authors

Qiaoqiao Chen

Yiwen Chen

Chenxuan Bao

Huayuan Xiang

Qing Gao

Lingxiang Mao

Affiliations

Soon will be listed here.

Abstract

The process of viruses entering host cells is complex, involving multiple aspects of the molecular organization of the cell membrane, viral proteins, the interaction of receptor molecules, and cellular signaling. Most viruses depend on endocytosis for uptake, when viruses reach the appropriate location, they are released from the vesicles, undergo uncoating, and release their genomes. Heat shock cognate protein 70(HSC70): also known as HSPA8, a protein involved in mediating clathrin-mediated endocytosis (CME), is involved in various viral entry processes. In this mini-review, our goal is to provide a summary of the function of HSC70 in viral entry. Understanding the interaction networks of HSC70 with viral proteins helps to provide new directions for targeted therapeutic strategies against viral infections.

Citing Articles

Discovery and Evaluation of Inhibitors of the SARS-CoV-2 Spike Protein-HSPA8 Complex Towards Developing COVID-19 Therapeutic Drugs.

Navhaya L, Matsebatlela T, Monama M, Makhoba X Viruses. 2024; 16(11).

PMID: 39599841 PMC: 11599135. DOI: 10.3390/v16111726.

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