RNA Biogenesis and RNA Metabolism Factors As R-loop Suppressors: a Hidden Role in Genome Integrity

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2024 Jul 10

PMID 38986581

Authors

Rosa Luna

Belen Gomez-Gonzalez

Andres Aguilera

Affiliations

Soon will be listed here.

Abstract

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to the accumulation of DNA-RNA hybrids and R-loops. In addition to physiological roles, R-loops interfere with DNA replication and repair, providing a molecular scenario for the origin of genome instability. Here, we review current knowledge on the multiple RNA factors that prevent or resolve R-loops and consequent transcription-replication conflicts and thus act as modulators of genome dynamics.

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