The Potential Use of Liposome-mediated Antiviral Therapy

Overview

Journal Antiviral Res

Publisher Elsevier

Date 1985 Jun 1

PMID 3896138

Citations 8

Authors

W C Koff

I J Fidler

Affiliations

Soon will be listed here.

Abstract

The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of virus diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication with in these cells.

Citing Articles

The systemic activation of macrophages by liposomes containing immunomodulators.

Nayar R, Fidler I Springer Semin Immunopathol. 1985; 8(4):413-28.

PMID: 4089759 DOI: 10.1007/BF01857394.

Liposomes in treatment of infectious diseases.

Emmen F, Storm G Pharm Weekbl Sci. 1987; 9(3):162-71.

PMID: 3302929 DOI: 10.1007/BF01967536.

Liposomes as carriers of antimicrobial agents.

Lopez-Berestein G Antimicrob Agents Chemother. 1987; 31(5):675-8.

PMID: 3300535 PMC: 174813. DOI: 10.1128/AAC.31.5.675.

Immunopotentiation of the humoral response by liposomes: encapsulation versus covalent linkage.

Shahum E, Therien H Immunology. 1988; 65(2):315-7.

PMID: 3192275 PMC: 1384931.

Increased efficacy of phosphonoformate and phosphonoacetate inhibition of herpes simplex virus type 2 replication by encapsulation in liposomes.

Szoka Jr F, Chu C Antimicrob Agents Chemother. 1988; 32(6):858-64.

PMID: 2843083 PMC: 172296. DOI: 10.1128/AAC.32.6.858.

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