Liposomes in Treatment of Infectious Diseases

Overview

Journal Pharm Weekbl Sci

Specialty Pharmacy

Date 1987 Jun 19

PMID 3302929

Citations 5

Authors

F Emmen

G Storm

Affiliations

Soon will be listed here.

Abstract

In reviewing the literature about the potential of liposomes in the therapy of infections caused by protozoa, bacteria, fungi and viruses, it can be concluded that liposomal encapsulation may improve the therapeutic index of anti-infectious drugs. The improved therapeutic index may be a result of a reduction in drug toxicity and/or an enhanced drug delivery at the intracellular site of infection. Furthermore, attention is paid to the therapeutic utility of liposome-encapsulated immunomodulators in treatment of infections.

Citing Articles

Liposome encapsulation of clofazimine reduces toxicity in vitro and in vivo and improves therapeutic efficacy in the beige mouse model of disseminated Mycobacterium avium-M. intracellulare complex infection.

MEHTA R Antimicrob Agents Chemother. 1996; 40(8):1893-902.

PMID: 8843300 PMC: 163436. DOI: 10.1128/AAC.40.8.1893.

Liposomes as carriers of antimicrobial agents or immunomodulatory agents in the treatment of infections.

Lokerse A, ten Kate M, Melissen P, van Vianen W, Van Etten E Eur J Clin Microbiol Infect Dis. 1993; 12 Suppl 1:S61-7.

PMID: 8477767 DOI: 10.1007/BF02389881.

Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice.

Duzgunes N, Perumal V, Kesavalu L, Goldstein J, Debs R, GANGADHARAM P Antimicrob Agents Chemother. 1988; 32(9):1404-11.

PMID: 3196002 PMC: 175877. DOI: 10.1128/AAC.32.9.1404.

Effect of lipid composition on activity of liposome-entrapped ampicillin against intracellular Listeria monocytogenes.

Lokerse A, Roerdink F Antimicrob Agents Chemother. 1988; 32(10):1560-4.

PMID: 3142339 PMC: 175919. DOI: 10.1128/AAC.32.10.1560.

Chloroquine blood levels after administration of the liposome-encapsulated drug in relation to therapy of murine malaria.

Peeters P, de Leest K, Eling W, Crommelin D Pharm Res. 1989; 6(9):787-93.

PMID: 2682591 DOI: 10.1023/a:1015927614920.

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