Regulating Epithelial-mesenchymal Plasticity from 3D Genome Organization

Overview

Journal Commun Biol

Specialty Biology

Date 2024 Jun 20

PMID 38902393

Authors

Qing You Pang

Yi-Chia Chiu

Ruby Yun-Ju Huang

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes.

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