Genotype × environment Interactions in Gene Regulation and Complex Traits

Overview

Journal Nat Genet

Specialty Genetics

Date 2024 Jun 10

PMID 38858456

Authors

Carly Boye

Shreya Nirmalan

Ali Ranjbaran

Francesca Luca

Affiliations

Soon will be listed here.

Abstract

Genotype × environment interactions (GxE) have long been recognized as a key mechanism underlying human phenotypic variation. Technological developments over the past 15 years have dramatically expanded our appreciation of the role of GxE in both gene regulation and complex traits. The richness and complexity of these datasets also required parallel efforts to develop robust and sensitive statistical and computational approaches. Although our understanding of the genetic architecture of molecular and complex traits has been maturing, a large proportion of complex trait heritability remains unexplained. Furthermore, there are increasing efforts to characterize the effect of environmental exposure on human health. We therefore review GxE in human gene regulation and complex traits, advocating for a comprehensive approach that jointly considers genetic and environmental factors in human health and disease.

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