Going Global by Adapting Local: A Review of Recent Human Adaptation

Overview

Journal Science

Specialty Science

Date 2016 Nov 16

PMID 27846491

Citations 141

Authors

Shaohua Fan

Matthew E B Hansen

Yancy Lo

Sarah A Tishkoff

Affiliations

Soon will be listed here.

Abstract

The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping of genetic variants associated with adaptations to regional living conditions and dietary practices. Ongoing efforts in sequencing genomes of indigenous populations, accompanied by the growing availability of "-omics" and ancient DNA data, promises a new era in our understanding of recent human evolution and the origins of variable traits and disease risks.

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