Efferocytosis in Dendritic Cells: an Overlooked Immunoregulatory Process

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Jun 5

PMID 38835772

Authors

Yanyan Ma

Tangxing Jiang

Xun Zhu

Yizhou Xu

Ke Wan

Tingxuan Zhang

Miaorong Xie

Affiliations

Soon will be listed here.

Abstract

Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.

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