Rocks: Multifunctional Kinases in Cell Behaviour

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2003 Jun 5

PMID 12778124

Citations 805

Authors

Kirsi Riento

Anne J Ridley

Affiliations

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Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

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