Strategies for the Enhancement of Secondary Metabolite Production Via Biosynthesis Gene Cluster Regulation in

Overview

Journal J Fungi (Basel)

Date 2024 May 24

PMID 38786667

Authors

Xiao Jia

Jiayi Song

Yijian Wu

Sai Feng

Zeao Sun

Yan Hu

Mengxue Yu

Rui Han

Bin Zeng

Affiliations

Soon will be listed here.

Abstract

The filamentous fungus () has been extensively used for the biosynthesis of numerous secondary metabolites with significant applications in agriculture and food and medical industries, among others. However, the identification and functional prediction of metabolites through genome mining in are hindered by the complex regulatory mechanisms of secondary metabolite biosynthesis and the inactivity of most of the biosynthetic gene clusters involved. The global regulatory factors, pathway-specific regulatory factors, epigenetics, and environmental signals significantly impact the production of secondary metabolites, indicating that appropriate gene-level modulations are expected to promote the biosynthesis of secondary metabolites in . This review mainly focuses on illuminating the molecular regulatory mechanisms for the activation of potentially unexpressed pathways, possibly revealing the effects of transcriptional, epigenetic, and environmental signal regulation. By gaining a comprehensive understanding of the regulatory mechanisms of secondary metabolite biosynthesis, strategies can be developed to enhance the production and utilization of these metabolites, and potential functions can be fully exploited.

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