Controlled Oxygen Delivery to Power Tissue Regeneration

Overview

Journal Nat Commun

Specialty Biology

Date 2024 May 22

PMID 38778053

Authors

Elizabeth Zoneff

Yi Wang

Colin Jackson

Oliver Smith

Serena Duchi

Carmine Onofrillo

Brooke Farrugia

Simon E Moulton

Richard Williams

Clare Parish

David R Nisbet

Lilith M Caballero-Aguilar

Affiliations

Soon will be listed here.

Abstract

Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.

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