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Invariant γδTCR Natural Killer-like Effector T Cells in the Naked Mole-rat

Overview

Overview

Journal Nat Commun

Specialty Biology

Date 2024 May 18

PMID 38762584

Authors

Authors

Guillem Sanchez Sanchez

Stephan Emmrich

Maria Georga

Ariadni Papadaki

Sofia Kossida

Andrei Seluanov

Vera Gorbunova

David Vermijlen

Affiliations

Affiliations

Soon will be listed here.

Abstract

The naked mole-rat (Heterocephalus glaber) is a long-lived rodent species showing resistance to the development of cancer. Although naked mole-rats have been reported to lack natural killer (NK) cells, γδ T cell-based immunity has been suggested in this species, which could represent an important arm of the immune system for antitumor responses. Here, we investigate the biology of these unconventional T cells in peripheral tissues (blood, spleen) and thymus of the naked mole-rat at different ages by TCR repertoire profiling and single-cell gene expression analysis. Using our own TCR annotation in the naked mole-rat genome, we report that the γδ TCR repertoire is dominated by a public invariant Vγ4-2/Vδ1-4 TCR, containing the complementary-determining-region-3 (CDR3)γ CTYWDSNYAKKLF / CDR3δ CALWELRTGGITAQLVF that are likely generated by short-homology-repeat-driven DNA rearrangements. This invariant TCR is specifically found in γδ T cells expressing genes associated with NK cytotoxicity and is generated in both the thoracic and cervical thymus of the naked mole-rat until adult life. Our results indicate that invariant Vγ4-2/Vδ1-4 NK-like effector T cells in the naked mole-rat can contribute to tumor immunosurveillance by γδ TCR-mediated recognition of a common molecular signal.

Citing Articles

Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat.

Gunbin K, Kopeina G, Zhivotovsky B, Zamaraev A Biol Direct. 2024; 19(1):58.

PMID: 39075541 PMC: 11285450. DOI: 10.1186/s13062-024-00503-z.

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