The F-actin Bundler SWAP-70 Promotes Tumor Metastasis

Overview

Journal Life Sci Alliance

Specialties Biochemistry
Biology
Cell Biology
Molecular Biology

Date 2024 May 17

PMID 38760173

Authors

Chao-Yuan Chang

Glen Pearce

Viktoria Betaneli

Tatsiana Kapustsenka

Kamran Hosseini

Elisabeth Fischer-Friedrich

Denis Corbeil

Jana Karbanova

Anna Taubenberger

Bjorn Dahncke

Martina Rauner

Giulia Furesi

Sven Perner

Fabian Rost

Rolf Jessberger

Affiliations

Soon will be listed here.

Abstract

Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the unique F-actin binding and bundling protein SWAP-70 contributes importantly to metastasis. Orthotopic, ectopic, and short-term tail vein injection mouse breast and lung cancer models revealed a strong positive dependence of lung and bone metastasis on SWAP-70. Breast cancer cell growth, migration, adhesion, and invasion assays revealed SWAP-70's key role in these metastasis-related cell features and the requirement for SWAP-70 to bind F-actin. Biophysical experiments showed that tumor cell stiffness and deformability are negatively modulated by SWAP-70. Together, we present a hitherto undescribed, unique F-actin modulator as an important contributor to tumor metastasis.

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