Adaptive Evolution of Antioxidase-related Genes in Hypoxia-tolerant Mammals

Overview

Journal Front Genet

Date 2024 May 10

PMID 38725483

Authors

Qiu-Ping Wang

Chao-Yang Luo

Xiong-Hui Xu

Wen-Xian Hu

Yu-Lin Gai

You-Jing Gong

Yuan Mu

Affiliations

Soon will be listed here.

Abstract

To cope with the damage from oxidative stress caused by hypoxia, mammals have evolved a series of physiological and biochemical traits, including antioxidant ability. Although numerous research studies about the mechanisms of hypoxia evolution have been reported, the molecular mechanisms of antioxidase-related genes in mammals living in different environments are yet to be completely understood. In this study, we constructed a dataset comprising 7 antioxidase-related genes (, , , , , , and ) from 43 mammalian species to implement evolutionary analysis. The results showed that six genes (, , , , , and ) have undergone divergent evolution based on the free-ratio (M1) model. Furthermore, multi-ratio model analyses uncovered the divergent evolution between hypoxic and non-hypoxic lineages, as well as various hypoxic lineages. In addition, the branch-site model identified 9 positively selected branches in 6 genes (, , , , , and ) that contained 35 positively selected sites, among which 31 positively selected sites were identified in hypoxia-tolerant branches, accounting for 89% of the total number of positively selected sites. Interestingly, 65 parallel/convergent sites were identified in the 7 genes. In summary, antioxidase-related genes are subjected to different selective pressures among hypoxia-tolerant species living in different habitats. This study provides a valuable insight into the molecular evolution of antioxidase-related genes in hypoxia evolution in mammals.

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