Identification of a Hemorrhagic Determinant in TcdA and TcsH

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2024 May 6

PMID 38709085

Authors

Yangling Zheng

Qi Yang

Jianhua Luo

Yuanyuan Zhang

Xingxing Li

Liuqing He

Chao Ma

Liang Tao

Affiliations

Soon will be listed here.

Abstract

Importance: and infections often cause hemorrhage in the affected tissues and organs, which is mainly attributed to their hemorrhagic toxins, TcsH and TcdA. In this study, we demonstrate that TcsH and TcdA, but not other related toxins. including toxin B and TcsL, induce severe hepatic hemorrhage in mice. We further determine that a small region in TcsH and TcdA is critical for the hemorrhagic toxicity but not cytotoxicity or lethality of these toxins. Based on these results, we propose that the hemorrhagic toxicity of TcsH and TcdA is due to an uncharacterized mechanism, such as the presence of an unknown receptor, and future studies to identify the interactive host factors are warranted.

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