Structure and Mode of Action of Clostridial Glucosylating Toxins: the ABCD Model

Overview

Journal Trends Microbiol

Date 2008 Apr 9

PMID 18394902

Citations 140

Authors

Thomas Jank

Klaus Aktories

Affiliations

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Abstract

Toxins A and B, which are the major virulence factors of antibiotic-associated diarrhea and pseudomembranous colitis caused by Clostridium difficile, are the prototypes of the family of clostridial glucosylating toxins. The toxins inactivate Rho and Ras proteins by glucosylation. Recent findings on the autocatalytic processing of the toxins and analysis of the crystal structures of their domains have made a revision of the current model of their actions on the eukaryotic target cells necessary.

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