Effect of Toxin A and B of Clostridium Difficile on Rabbit Ileum and Colon

Overview

Journal Gut

Specialty Gastroenterology

Date 1986 Jan 1

PMID 3949240

Citations 56

Authors

T J Mitchell

J M Ketley

S C Haslam

J Stephen

D W Burdon

D C Candy

R Daniel

Affiliations

Soon will be listed here.

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

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