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Biological Functions and Clinic Significance of SAF‑A (Review)

Overview
Journal Biomed Rep
Specialty Biochemistry
Date 2024 Apr 26
PMID 38665420
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Abstract

As one member of the heterogeneous ribonucleoprotein (hnRNP) family, scaffold attachment factor A (SAF-A) or hnRNP U, is an abundant nuclear protein. With RNA and DNA binding activities, SAF-A has multiple functions. The present review focused on the biological structure and different roles of SAF-A and SAF-A-related diseases. It was found that SAF-A maintains the higher-order chromatin organization via RNA and DNA, and regulates transcription at the initiation and elongation stages. In addition to regulating pre-mRNA splicing, mRNA transportation and stabilization, SAF-A participates in double-strand breaks and mitosis repair. Therefore, the aberrant expression and mutation of SAF-A results in tumors and impaired neurodevelopment. Moreover, SAF-A may play a role in the anti-virus system. In conclusion, due to its essential biological functions, SAF-A may be a valuable clinical prediction factor or therapeutic target. Since the role of SAF-A in tumors and viral infections may be controversial, more animal experiments and clinical assays are needed.

References
1.
Sharp J, Perea-Resa C, Wang W, Blower M . Cell division requires RNA eviction from condensing chromosomes. J Cell Biol. 2020; 219(11). PMC: 7549315. DOI: 10.1083/jcb.201910148. View

2.
Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller S . Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis. Mol Cell Biol. 2015; 35(15):2699-713. PMC: 4524121. DOI: 10.1128/MCB.01312-14. View

3.
Helbig R, Fackelmayer F . Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain. Chromosoma. 2003; 112(4):173-82. DOI: 10.1007/s00412-003-0258-0. View

4.
Hegde M, Dutta A, Yang C, Mantha A, Hegde P, Pandey A . Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. 2016; 7(34):54430-54444. PMC: 5342353. DOI: 10.18632/oncotarget.9914. View

5.
Jiao W, Chen Y, Song H, Li D, Mei H, Yang F . HPSE enhancer RNA promotes cancer progression through driving chromatin looping and regulating hnRNPU/p300/EGR1/HPSE axis. Oncogene. 2018; 37(20):2728-2745. DOI: 10.1038/s41388-018-0128-0. View