Long Noncoding RNA Promoted Apoptosis and Increased Cisplatin Chemosensitivity Via Regulating the HnRNP-U-GADD45A Axis in Lung Squamous Cell Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Dec 13

PMID 29228625

Citations 22

Authors

Ling Li

Ji-Ye Yin

Fa-Zhong He

Ma-Sha Huang

Tao Zhu

Yuan-Feng Gao

Yi-Xin Chen

Dong-Bo Zhou

Xiang Chen

Lun-Quan Sun

Wei Zhang

Hong-Hao Zhou

Zhao-Qian Liu

Affiliations

Soon will be listed here.

Abstract

Chemotherapeutic insensitivity remains one of the major obstacles in clinical treatment of lung squamous cell carcinoma (LSCC). Recently, increasing evidence has suggested that long non-coding RNAs (lncRNAs) promote tumorigenesis in many cancer types. However, the potential biological roles and regulatory mechanisms of lncRNAs in response to cisplatin treatment are poorly understood. Here, we found that lncRNA (surfactant associated 1, pseudogene), highly expressed in lung, was down-regulated in LSCC tissues and could be induced upon cisplatin treatment in LSCC cells. Elevated induced apoptosis and enhanced the sensitivity to cisplatin of LSCC cells. We further identified that hnRNP-U (heterogeneous nuclear ribonucleoprotein U) was down-regulated in LSCCs and positively correlated with patients' poor prognosis as well as SFTA1P. Mechanistic studies revealed that could up-regulate hnRNP-U expression. In addition, we identified that hnRNP-U enhanced cisplatin-induced apoptosis through up-regulation of GADD45A, high expression of which was correlated with good prognosis in LSCC patients. Our findings demonstrated that might serve as a useful biomarker for LSCC diagnosis and a predictor for cisplatin chemotherapy response in patients with LSCC.

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