Single Cell Atlas: a Single-cell Multi-omics Human Cell Encyclopedia

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2024 Apr 19

PMID 38641842

Authors

Lu Pan

Paolo Parini

Roman Tremmel

Joseph Loscalzo

Volker M Lauschke

Bradley A Maron

Paola Paci

Ingemar Ernberg

Nguan Soon Tan

Zehuan Liao

Weiyao Yin

Sundararaman Rengarajan

Xuexin Li

Affiliations

Soon will be listed here.

Abstract

Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth characterizations of datasets from five single-cell omics, spatial transcriptomics, and two bulk omics across 125 healthy adult and fetal tissues. We construct its complement web-based platform, the Single Cell Atlas (SCA, www.singlecellatlas.org ), to enable vast interactive data exploration of deep multi-omics signatures across human fetal and adult tissues. The atlas resources and database queries aspire to serve as a one-stop, comprehensive, and time-effective resource for various omics studies.

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