HLA-DR Antigens in Primary Biliary Cirrhosis: Lack of Association

Overview

Journal Gut

Specialty Gastroenterology

Date 1985 Jun 1

PMID 3859460

Citations 9

Authors

M F Bassendine

P J Dewar

O F James

Affiliations

Soon will be listed here.

Abstract

A study of HLA-DR antigen in 75 patients with primary biliary cirrhosis has been carried out in order to test the hypothesis that genetic factors related to genes controlling immune responses might be important in the pathogenesis of primary biliary cirrhosis. The frequencies of HLA-DR locus antigens was not significantly different from those in 200 normal controls, nor were those of tissue antigens on the A and B loci. No HLA-DR antigen was significantly associated with the appearance of granulomata on liver biopsy (possibly good prognosis) or with raised serum bilirubin (possibly bad prognosis); nor was there any association between any HLA-DR antigen and adverse reactions to D-penicillamine treatment in 17 patients with such adverse reactions. It is concluded that genetic traits related to HLA antigens studied are probably not important in the aetiology of the disease.

Citing Articles

Association of human leukocyte antigen class II with susceptibility to primary biliary cirrhosis: a systematic review and meta-analysis.

Qin B, Wang J, Chen J, Liang Y, Yang Z, Zhong R PLoS One. 2013; 8(11):e79580.

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Human leukocyte antigen in primary biliary cirrhosis: an old story now reviving.

Invernizzi P Hepatology. 2011; 54(2):714-23.

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Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis.

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Genomic variants associated with primary biliary cirrhosis.

Selmi C, Torok N, Affronti A, Gershwin M Genome Med. 2010; 2(1):5.

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Genetics and genomics of primary biliary cirrhosis.

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