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Histocompatibility Antigens in Active Chronic Hepatitis and Primary Biliary Cirrhosis

Overview
Journal Br Med J
Specialty General Medicine
Date 1974 Sep 7
PMID 4422709
Citations 21
Authors
R M Galbraith
A L Eddleston
M G Smith
R Williams
R N McSween
G Watkinson
H Dick
L A Kennedy
J R Batchelor
Affiliations
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Abstract

The frequency of antigens HL-A 1 (48%) and HL-A 8 (52%) in 54 patients with active chronic hepatitis from south-east England was significantly higher than in 89 control subjects from the same region (22% and 17% respectively). No correlation could be detected with the age and sex of the patients or with the presence of a particular immunological abnormality but the frequency of HL-A 1 and HL-A 8 was much lower in the nine patients who were positive for HBAg than in the 45 HBAg-negative cases. These results provide further evidence of the importance of genetic factors in active chronic hepatitis. In contrast the frequency of HL-A 1 and HL-A 8 in primary biliary cirrhosis, both in 45 patients from south-east England and in 28 patients from western Scotland, was not significantly different from that found in control groups from the same regions.

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References
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