Familial Occurrence of Primary Biliary Cirrhosis Associated with Hypergammaglobulinemia in Descendants: a Family Study
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Four sisters out of 6 suffered from primary biliary cirrhosis. Their fathed raised immunoglobulin levels without signs of any disease. Australia antigen was not found in the patients or their relatives. It is suggested that these observations indicate a genetic predisposition to immunologic abnormalities manifesting itself as a familial lack of immunoglobulin control.
Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis.
Shin S, Moh I, Woo Y, Jung S, Kim J, Park J World J Gastroenterol. 2017; 23(39):7191-7197.
PMID: 29093628 PMC: 5656467. DOI: 10.3748/wjg.v23.i39.7191.
The X-factor in primary biliary cirrhosis: monosomy X and xenobiotics.
Bianchi I, Lleo A, Bernuzzi F, Caliari L, Smyk D, Invernizzi P Auto Immun Highlights. 2015; 3(3):127-32.
PMID: 26000136 PMC: 4389075. DOI: 10.1007/s13317-012-0043-2.
Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies.
Milkiewicz M, Caballeria L, Smyk D, Milkiewicz P Auto Immun Highlights. 2015; 3(3):105-12.
PMID: 26000133 PMC: 4389078. DOI: 10.1007/s13317-012-0038-z.
Primary biliary cirrhosis: family stories.
Smyk D, Cholongitas E, Kriese S, Rigopoulou E, Bogdanos D Autoimmune Dis. 2011; 2011:189585.
PMID: 21687641 PMC: 3112499. DOI: 10.4061/2011/189585.
Familial clustering and genetic background of primary biliary cirrhosis in Japan.
Yanagisawa M, Takagi H, Takahashi H, Uehara M, Otsuka T, Yuasa K Dig Dis Sci. 2009; 55(9):2651-8.
PMID: 20012485 DOI: 10.1007/s10620-009-1057-0.