Localization of Anti-osteogenic Sarcoma Monoclonal Antibody 791T/36 in a Primary Human Osteogenic Sarcoma and Its Subsequent Xenograft in Immunodeprived Mice

Overview

Journal Cancer Immunol Immunother

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 1985 Jan 1

PMID 3856475

Citations 1

Authors

M V Pimm

A C Perkins

N C Armitage

R W Baldwin

Affiliations

Soon will be listed here.

Abstract

A primary human osteogenic sarcoma was visualized in situ by external gamma-camera imaging following administration of 131I-labelled anti-osteogenic sarcoma monoclonal antibody 791T/36. A xenograft of the tumour established in immunodeprived mice also showed localization of 131I-791T/36 determined by both gamma-camera imaging and organ distribution studies. Radiolabelled normal immunoglobulin showed no tumour localization. Expression of the 791T/36-defined antigen on xenografted tissue was further confirmed by reaction of its in vitro-cultured cells with fluorescein-labelled 791T/36 antibody.

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