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Tomoscintigraphy for Detecting Gastrointestinal and Medullary Thyroid Cancers: First Clinical Results Using Radiolabelled Monoclonal Antibodies Against Carcinoembryonic Antigen

Overview
Journal Br Med J (Clin Res Ed)
Specialty General Medicine
Date 1982 Nov 20
PMID 6814596
Citations 32
Authors
C Berche
J P Mach
J D Lumbroso
C Langlais
F Aubry
F Buchegger
S Carrel
P Rougier
C Parmentier
M TUBIANA
Affiliations
Soon will be listed here.
Abstract

Transaxial tomoscintigraphy (or single-photon emission computerised tomography) was used to detect secondary deposits of carcinoma in 17 patients who had been injected with iodine-131-labelled monoclonal antibodies against carcinoembryonic antigen. Of 17 tumor sites studied by tomoscintigraphy 16 were detected (sensitivity 94%); five sites had a volume smaller than 10 cm3. Tomoscintigraphy also detected three unknown tumour deposits later confirmed by surgery or radiology. In contrast, when 21 tumour sites in the same patients were studied by rectilinear scintigraphy, only nine tumour sites were detected (sensitivity 43%), of which eight had a volume larger than 50 cm3.

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Imaging of recurrent intestinal carcinoma with indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody CEA102.

Nakada K, Sakamoto J, Watanabe T, Itoh K, Akiyama S, Takagi H Jpn J Cancer Res. 1997; 88(6):605-13.

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Pretargeted immunoscintigraphy in patients with medullary thyroid carcinoma.

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Radioimmunoscintigraphy with technetium-99m labelled monoclonal antibody, 1A3, in colorectal cancer.

Granowska M, Britton K, Mather S, Morris G, Ellison D, Soobramoney S Eur J Nucl Med. 1993; 20(8):690-8.

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Localization of hepatic metastases by radiolabelled anti-carcinoembryonic antigen antibody and meta-iodobenzylguanidine in a patient with medullary thyroid carcinoma.

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References
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