Localisation of Human Osteosarcoma by Antitumour Monoclonal Antibody

Overview

Journal J Bone Joint Surg Br

Specialties General Surgery
Orthopedics

Date 1983 Nov 1

PMID 6358231

Citations 8

Authors

P A Farrands

A Perkins

L Sully

J S Hopkins

M V Pimm

R W Baldwin

J D Hardcastle

Affiliations

Soon will be listed here.

Abstract

Immunoscintigraphy using radioisotope-labelled monoclonal antibody prepared against osteosarcoma 791T cells was used to detect a primary osteosarcoma. The eight-centimetre tumour was detected using rectilinear scintigraphy of 131I-labelled antibodies. Image enhancement was achieved by subtraction of blood-pool radioactivity labelled with technetium-99m. The ratio of tumour to non-tumour uptake of radioactivity (5:1) suggested that antibody targeting of therapeutic agents is feasible.

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