Gene Rs828867 G>A Polymorphism Reduces Neuroblastoma Risk in Chinese Children

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Mar 21

PMID 38509981

Authors

Xinxin Zhang

Bo Wang

Lei Lin

Chunlei Zhou

Jinhong Zhu

Haiyan Wu

Jing He

Affiliations

Soon will be listed here.

Abstract

Objective: Neuroblastoma (NB) is a prevalent pediatric tumor originating from primordial neural crest cells. As one of the latest epigenetics investigations focuses, RNA 5-methylcytosine (m5C) is closely related to cancer risk. TET methylcytosine dioxygenase 3 (TET3) is a demethylase for m5C modification. Whether there is an association between gene polymorphisms and neuroblastoma risk remains unclear.

Methods: We conducted an epidemiological study in 402 patients and 473 controls to evaluate the relationship between gene SNPs (rs7560668 T > C, rs828867 G > A, and rs6546891 A > G) and NB susceptibility.

Results: Our results showed that rs828867 G > A significantly reduced NB risk in Chinese children [GA vs. GG, adjusted odds ratio (OR) = 0.72, 95% confidence interval (CI) = 0.52-0.98, 0.040; GA/AA vs. GG, adjusted OR = 0.74, 95% CI = 0.55-0.998, 0.048]. Individuals with 2-3 risk genotypes had a significantly higher NB risk than those with 0-1 risk genotypes (adjusted OR = 1.40, 95% CI = 1.04-1.88, 0.027). The stratified analysis showed that the rs828867 G > A associated with decreased NB risk is remarkable among children aged >18 months (adjusted OR = 0.67, 95% CI = 0.46-0.96, 0.029) and patients at clinical III + IV stages (adjusted OR = 0.67, 95% CI = 0.45-0.98, 0.040). Compared with the 0-1 risk genotype, the concurrence of 2-3 risk genotypes significantly increased NB risk in the following subgroups: children aged >18 months and patients at clinical III + IV stages. GTEx analysis suggested that rs828867 G > A was significantly associated with and mRNA expression.

Conclusions: Overall, our results revealed that rs828867 G > A in the gene is significantly associated with predisposition to NB.

Citing Articles

HOTTIP rs1859168 C > A polymorphism reduces neuroblastoma susceptibility in Chinese children.

Zhang T, Yin H, Guo J, Chang J, Li M, He J Eur J Pediatr. 2024; 184(1):104.

PMID: 39718648 DOI: 10.1007/s00431-024-05942-4.

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