Gene Polymorphisms and Neuroblastoma Susceptibility in Chinese Children

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Dec 13

PMID 34897032

Citations 6

Authors

Yong Li

Tongyi Lu

Jian Wang

Zhenjian Zhuo

Lei Miao

Zhonghua Yang

Jiao Zhang

Jiwen Cheng

Haixia Zhou

Suhong Li

Li Li

Jing He

Aiwu Li

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma (NB) is the most common extracranial tumor in children. YTHDC1, a member of RNA methylation modification binding proteins, plays critical roles in tumor occurrence and metastasis. However, it is unclear whether gene polymorphisms are related to NB susceptibility. Herein, we aimed to evaluate the association between gene polymorphisms (rs2293596 T>C, rs2293595 T>C, rs3813832 T>C) and susceptibility of NB by logistic regression models. In this eight-center case-control study, 898 patients with NB and 1734 healthy controls were genotyped by TaqMan assay. The results showed that rs3813832 TC genotype could significantly reduce the susceptibility of NB compared with the TT genotype [adjusted odds ratio (AOR) = 0.81, 95% confidence interval (CI) = 0.68-0.96, = 0.018]. Combined genotype analysis revealed that individuals with 3 protective genotypes had a prominently lower NB risk than those with 0-2 protective genotypes (AOR = 0.80, 95% CI = 0.68-0.94, = 0.006). The stratified analysis also demonstrated the protective effect of rs3813832 TC/CC and 3 protective genotypes in certain subgroups. Further functional experiments revealed that siRNA-554, targeting the area near the rs3813832 T>C polymorphism site, could observably inhibit the proliferation and migration of NB cells. In conclusion, our findings highlight the involvement of gene and its genetic variants in the etiology of NB.

Citing Articles

gene rs828867 G>A polymorphism reduces neuroblastoma risk in Chinese children.

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Genetic variants of m7G modification genes influence neuroblastoma susceptibility.

Liu J, Deng C, Lin H, Zhang X, Zhu J, Zhou C Heliyon. 2024; 10(1):e23658.

PMID: 38173492 PMC: 10761801. DOI: 10.1016/j.heliyon.2023.e23658.

rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children.

Zhang X, Zhou C, Zhao Y, Deng C, Wu H, Zhuo Z J Cancer. 2024; 15(2):526-532.

PMID: 38169562 PMC: 10758041. DOI: 10.7150/jca.89271.

RNA N6-methyladenosine reader IGF2BP3 interacts with MYCN and facilitates neuroblastoma cell proliferation.

Zhu K, Gao T, Wang Z, Zhang L, Tan K, Lv Z Cell Death Discov. 2023; 9(1):151.

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YY1 transcription factor induces proliferation and aerobic glycolysis of neuroblastoma cells via LDHA regulation.

Wang Q, Fan W, Liang B, Hou B, Jiang Z, Li C Exp Ther Med. 2022; 25(1):37.

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