Competitive Fungal Commensalism Mitigates Candidiasis Pathology

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2024 Mar 18

PMID 38497819

Authors

Jarmila Sekeresova Kralova

Catalina Donic

Bareket Dassa

Ilana Livyatan

Paul Mathias Jansen

Shifra Ben-Dor

Lena Fidel

Sebastien Trzebanski

Lian Narunsky-Haziza

Omer Asraf

Ori Brenner

Hagit Dafni

Ghil Jona

Sigalit Boura-Halfon

Noa Stettner

Eran Segal

Sascha Brunke

Yitzhak Pilpel

Ravid Straussman

David Zeevi

Petra Bacher

Bernhard Hube

Neta Shlezinger

Steffen Jung

Affiliations

Soon will be listed here.

Abstract

The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.

Citing Articles

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