and Synergistically Protect from Colitis by Promoting ILC3 in the Gut

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Mar 12

PMID 38470269

Authors

Joana Gaifem

Ana Mendes-Frias

Mathis Wolter

Alex Steimle

Maria Jose Garzon

Carles Ubeda

Clarisse Nobre

Abigail Gonzalez

Salome S Pinho

Cristina Cunha

Agostinho Carvalho

Antonio Gil Castro

Mahesh S Desai

Fernando Rodrigues

Ricardo Silvestre

Affiliations

Soon will be listed here.

Abstract

Importance: The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel strategies to tackle IBD. Herein, we revealed a synergistic interaction between two commensal bacterial strains, and , which induce protection against both acute and chronic models of colitis induction, by enhancing epithelial barrier integrity and promoting group 3 innate lymphoid cells in the colonic mucosa. This study provides a novel insight on how commensal bacteria can beneficially act to promote intestinal homeostasis, which may open new avenues toward the use of microbiome-derived strategies to tackle IBD.

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