Co-treatment with the Seed of L. and the Aerial Part of Synergistically Suppresses Aβ-induced Neurotoxicity by Altering APP Processing

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2024 Mar 8

PMID 38455162

Authors

Mei Tong He

Ji Hyun Kim

Eun Ju Cho

Affiliations

Soon will be listed here.

Abstract

Accumulation of β-amyloid peptide (Aβ) induces neurotoxicity, which is the primary risk factor in the pathogenesis of Alzheimer's disease (AD). The cleavage of amyloid precursor protein (APP) by the β- (BACE) and γ- (PS1, PS2) secretases is a critical step in the amyloidogenic pathway. The induction of neuronal apoptosis by Aβ involves increased expression of B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and decreased Bcl-2 expression. The seed of L. (CTS) and the aerial part of (TC) are traditional herbs used to treat several neurodegenerative diseases. In this study, the neuroprotective effects of co-treatment with CTS and TC on Aβ-induced neurotoxicity in SH-SY5Y neuroblastoma cells and the underlying mechanisms were investigated. CTS, TC, and the co-treatment (CTS + TC) were added to Aβ-treated SH-SY5Y cells. CTS + TC synergistically increased cell viability and inhibited reactive oxygen species production. CTS + TC resulted in significant downregulation of BACE, PS1, PS2, and APP, as well as the 99-aa C-terminal domain of APP, compared with either CTS or TC alone. Compared with the single herbs, co-treatment with CTS and TC markedly decreased the expression of Bax and increased the expression of Bcl-2, consistent with its anti-apoptotic effects. These findings suggest that co-treatment with CTS and TC may be useful for AD prevention.

Citing Articles

Farnesylthiosalicylic Acid Through Inhibition of Galectin-3 Improves Neuroinflammation in Alzheimer Disease via Multiple Pathways.

Qiu Q, Li C, Zhao X, Yang M, Ding S, Liang H CNS Neurosci Ther. 2024; 30(11):e70127.

PMID: 39592913 PMC: 11598744. DOI: 10.1111/cns.70127.

Co-treatment with the seed of L. and the aerial part of synergistically suppresses Aβ-induced neurotoxicity by altering APP processing.

He M, Kim J, Cho E Food Sci Nutr. 2024; 12(3):1573-1580.

PMID: 38455162 PMC: 10916591. DOI: 10.1002/fsn3.3768.

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