Extract Ameliorates Ovalbumin-Induced Allergic Rhinitis by Inhibiting the IL-33/ST2 Axis and Regulating Epithelial Cell Dysfunction

Overview

Journal Foods

Specialty Biotechnology

Date 2024 Feb 24

PMID 38397588

Authors

Juan Jin

Yan Jing Fan

Thi Van Nguyen

Zhen Nan Yu

Chang Ho Song

So-Young Lee

Hee Soon Shin

Ok Hee Chai

Affiliations

Soon will be listed here.

Abstract

has traditionally been used as an herbal medicine due to its characteristics that protect against inflammation, hypertension, and mutagenesis. However, the effect of (CSE) on allergic rhinitis (AR) and its underlying mechanisms have yet to be thoroughly investigated. The current study explored the likely effect of CSE on AR in an ovalbumin (OVA)-induced AR mouse model. To this end, OVA-specific immunoglobulins, nasal symptoms, cytokine production, the infiltration of inflammatory cells, and nasal histopathology were assessed to determine the role of CSE against AR. The supplementation of CSE was found to suppress OVA-specific IgE, while OVA-specific IgG2a was increased in the serum. Further, CSE ameliorated the production of T helper type 2 (Th2) cytokines whereas it increased Th1 cytokine levels in nasal lavage fluid. Moreover, the CSE treatment group exhibited significant inhibition of IL-33/ST2 signaling. Subsequently, CES reversed the OVA-induced enhancement of epithelial permeability and upregulated E-cadherin, thus indicating that CES plays a protective role on epithelial barrier integrity. Altogether, the oral administration of CSE effectively controlled allergic response by restricting the buildup of inflammatory cells, enhancing nasal and lung histopathological traits, and regulating cytokines associated with inflammation. Collectively, the results show that the supplementation of CSE at different doses effectively regulated AR, thus suggesting the therapeutic efficiency of CSE in suppressing airway diseases.

Citing Articles

The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases.

Gu S, Wang R, Zhang W, Wen C, Chen C, Liu S Front Immunol. 2024; 15:1436437.

PMID: 39301028 PMC: 11410612. DOI: 10.3389/fimmu.2024.1436437.

References

Du L, Li J, Zhang X, Wang L, Zhang W, Yang M . Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-κB pathway activation. Food Nutr Res. 2019; 63. PMC: 6495109. DOI: 10.29219/fnr.v63.3392. View

Naser A, Lu Q, Chen Y . Trans-Compartmental Regulation of Tight Junction Barrier Function. Tissue Barriers. 2022; 11(4):2133880. PMC: 10606786. DOI: 10.1080/21688370.2022.2133880. View

Hamauzu Y, Yasui H, Inno T, Kume C, Omanyuda M . Phenolic profile, antioxidant property, and anti-influenza viral activity of Chinese quince (Pseudocydonia sinensis Schneid.), quince (Cydonia oblonga Mill.), and apple (Malus domestica Mill.) fruits. J Agric Food Chem. 2005; 53(4):928-34. DOI: 10.1021/jf0494635. View

Chen W, Huang Y, Yang M, Lee C, Chen C, Yeh C . Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation. Int Immunopharmacol. 2014; 22(2):409-13. DOI: 10.1016/j.intimp.2014.07.026. View

Hu J, Gao N, Zhang Y, Chen X, Li J, Bian F . IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020; 13(6):919-930. PMC: 7572432. DOI: 10.1038/s41385-020-0288-4. View

Nguyen T, Vo C, Vo V, Nguyen C, Pham T, Piao C . Ban Ameliorates Lower Airway Inflammation in Experimental Asthmatic Mouse Model via Nrf2/HO-1 and MAPK Signaling Pathway. Antioxidants (Basel). 2023; 12(6). PMC: 10295053. DOI: 10.3390/antiox12061301. View

Yahfoufi N, Alsadi N, Jambi M, Matar C . The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients. 2018; 10(11). PMC: 6266803. DOI: 10.3390/nu10111618. View

Eccles R . Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse. Br J Clin Pharmacol. 2006; 63(1):10-4. PMC: 2000711. DOI: 10.1111/j.1365-2125.2006.02833.x. View

Qin W, Deng T, Cui H, Zhang Q, Liu X, Yang X . Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK. Food Chem Toxicol. 2018; 114:78-87. DOI: 10.1016/j.fct.2018.02.028. View

10.

Calderon A, Dimond C, Choy D, Pappu R, Grimbaldeston M, Mohan D . Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD. Eur Respir Rev. 2023; 32(167). PMC: 9879340. DOI: 10.1183/16000617.0144-2022. View

11.

Lv C, Zhang Y, Shen L . Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis. Int Arch Allergy Immunol. 2018; 175(4):231-236. DOI: 10.1159/000486959. View

12.

Bui T, Piao C, Hyeon E, Fan Y, Nguyen T, Jung S . The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NFκBp65 and STAT3 signalings. Biomed Pharmacother. 2018; 109:1915-1923. DOI: 10.1016/j.biopha.2018.11.073. View

13.

Divekar R, Kita H . Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation. Curr Opin Allergy Clin Immunol. 2014; 15(1):98-103. PMC: 4346181. DOI: 10.1097/ACI.0000000000000133. View

14.

Small P, Keith P, Kim H . Allergic rhinitis. Allergy Asthma Clin Immunol. 2018; 14(Suppl 2):51. PMC: 6156899. DOI: 10.1186/s13223-018-0280-7. View

15.

Ge J, Liu Z, Zhong Z, Wang L, Zhuo X, Li J . Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery. Bioorg Chem. 2022; 124:105817. DOI: 10.1016/j.bioorg.2022.105817. View

16.

Jin J, Fan Y, Nguyen T, Yu Z, Song C, Lee S . Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-κB Signaling Pathway. Int J Mol Sci. 2023; 24(15). PMC: 10420321. DOI: 10.3390/ijms241512514. View

17.

Enomoto T, Nagasako-Akazome Y, Kanda T, Ikeda M, Dake Y . Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol. 2006; 16(5):283-9. View

18.

Zeng Y, Xue M, Zhang T, Sun S, Lin R, Li N . Soluble form of suppression of tumorigenicity-2 predicts clinical stability of inpatients with community-acquired pneumonia. Exp Biol Med (Maywood). 2021; 246(21):2297-2306. PMC: 8581825. DOI: 10.1177/15353702211027116. View

19.

Sin B, Togias A . Pathophysiology of allergic and nonallergic rhinitis. Proc Am Thorac Soc. 2011; 8(1):106-14. DOI: 10.1513/pats.201008-057RN. View

20.

Wheatley L, Togias A . Clinical practice. Allergic rhinitis. N Engl J Med. 2015; 372(5):456-63. PMC: 4324099. DOI: 10.1056/NEJMcp1412282. View