Bone Tissue Engineering Scaffolds: Materials and Methods

Overview

Journal 3D Print Addit Manuf

Date 2024 Feb 23

PMID 38389691

Authors

Shreeprasad S Manohar

Chinmoy Das

Vikramjit Kakati

Affiliations

Soon will be listed here.

Abstract

The wide development in biomedical, regenerative medicine, and surgical techniques has ensured that new technologies are developed to improve patient-specific treatment and care. Tissue engineering is a special field in biomedical engineering that works toward cell development using scaffolds. Bone tissue engineering is a separate branch of tissue engineering, in which the construction of bone, functionalities of bone, and bone tissue regeneration are studied in detail to repair or regenerate new functional bone tissues. In India alone, people suffering from bone diseases are extensive in numbers. Almost 15% to 20% of the population suffers from osteoporosis. Bone scaffolds are proving to be an excellent solution for osseous abnormalities or defect treatment. Scaffolds are three dimensional (3D) and mostly porous structures created to enhance new tissue growth. Bone scaffolds are specially designed to promote osteoinductive cell growth, expansion, and migration on their surface. This review article aims to provide an overview of possible bone scaffolding materials in practice, different 3D techniques to fabricate these scaffolds, and effective bone scaffold characteristics targeted by researchers to fabricate tissue-engineered bone scaffolds.

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References

Chocholata P, Kulda V, Babuska V . Fabrication of Scaffolds for Bone-Tissue Regeneration. Materials (Basel). 2019; 12(4). PMC: 6416573. DOI: 10.3390/ma12040568. View

Liu P, Chen W, Liu C, Tian M, Liu P . A novel poly (vinyl alcohol)/poly (ethylene glycol) scaffold for tissue engineering with a unique bimodal open-celled structure fabricated using supercritical fluid foaming. Sci Rep. 2019; 9(1):9534. PMC: 6606581. DOI: 10.1038/s41598-019-46061-7. View

Sukpaita T, Chirachanchai S, Pimkhaokham A, Ampornaramveth R . Chitosan-Based Scaffold for Mineralized Tissues Regeneration. Mar Drugs. 2021; 19(10). PMC: 8540467. DOI: 10.3390/md19100551. View

Short A, Koralla D, Deshmukh A, Wissel B, Stocker B, Calhoun M . Hydrogels That Allow and Facilitate Bone Repair, Remodeling, and Regeneration. J Mater Chem B. 2015; 3(40):7818-7830. PMC: 4675359. DOI: 10.1039/C5TB01043H. View

Chia H, Wu B . Recent advances in 3D printing of biomaterials. J Biol Eng. 2015; 9:4. PMC: 4392469. DOI: 10.1186/s13036-015-0001-4. View

Amini A, Laurencin C, Nukavarapu S . Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng. 2013; 40(5):363-408. PMC: 3766369. DOI: 10.1615/critrevbiomedeng.v40.i5.10. View

Wendels S, Averous L . Biobased polyurethanes for biomedical applications. Bioact Mater. 2020; 6(4):1083-1106. PMC: 7569269. DOI: 10.1016/j.bioactmat.2020.10.002. View

Mazzanti V, Malagutti L, Mollica F . FDM 3D Printing of Polymers Containing Natural Fillers: A Review of their Mechanical Properties. Polymers (Basel). 2019; 11(7). PMC: 6680682. DOI: 10.3390/polym11071094. View

Gregor A, Filova E, Novak M, Kronek J, Chlup H, Buzgo M . Designing of PLA scaffolds for bone tissue replacement fabricated by ordinary commercial 3D printer. J Biol Eng. 2017; 11:31. PMC: 5641988. DOI: 10.1186/s13036-017-0074-3. View

10.

Lantigua D, Wu X, Suvarnapathaki S, Nguyen M, Camci-Unal G . Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering. Bioengineering (Basel). 2021; 8(11). PMC: 8614748. DOI: 10.3390/bioengineering8110169. View

11.

Billiet T, Vandenhaute M, Schelfhout J, Van Vlierberghe S, Dubruel P . A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering. Biomaterials. 2012; 33(26):6020-41. DOI: 10.1016/j.biomaterials.2012.04.050. View

12.

Yeong W, Sudarmadji N, Yu H, Chua C, Leong K, Venkatraman S . Porous polycaprolactone scaffold for cardiac tissue engineering fabricated by selective laser sintering. Acta Biomater. 2009; 6(6):2028-34. DOI: 10.1016/j.actbio.2009.12.033. View

13.

Simunovic F, Finkenzeller G . Vascularization Strategies in Bone Tissue Engineering. Cells. 2021; 10(7). PMC: 8306064. DOI: 10.3390/cells10071749. View

14.

Sionkowska A, Gadomska M, Musial K, Piatek J . Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review. Molecules. 2020; 25(18). PMC: 7570474. DOI: 10.3390/molecules25184035. View

15.

Loh Q, Choong C . Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size. Tissue Eng Part B Rev. 2013; 19(6):485-502. PMC: 3826579. DOI: 10.1089/ten.TEB.2012.0437. View

16.

Tamay D, Dursun Usal T, Alagoz A, Yucel D, Hasirci N, Hasirci V . 3D and 4D Printing of Polymers for Tissue Engineering Applications. Front Bioeng Biotechnol. 2019; 7:164. PMC: 6629835. DOI: 10.3389/fbioe.2019.00164. View

17.

Filippi M, Born G, Chaaban M, Scherberich A . Natural Polymeric Scaffolds in Bone Regeneration. Front Bioeng Biotechnol. 2020; 8:474. PMC: 7253672. DOI: 10.3389/fbioe.2020.00474. View

18.

He B, Ou Y, Zhou A, Chen S, Zhao W, Zhao J . Functionalized d-form self-assembling peptide hydrogels for bone regeneration. Drug Des Devel Ther. 2016; 10:1379-88. PMC: 4833366. DOI: 10.2147/DDDT.S97530. View

19.

Elomaa L, Teixeira S, Hakala R, Korhonen H, Grijpma D, Seppala J . Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography. Acta Biomater. 2011; 7(11):3850-6. DOI: 10.1016/j.actbio.2011.06.039. View

20.

Hospodiuk M, Dey M, Sosnoski D, Ozbolat I . The bioink: A comprehensive review on bioprintable materials. Biotechnol Adv. 2017; 35(2):217-239. DOI: 10.1016/j.biotechadv.2016.12.006. View