Reduced Bik Expression Drives Low-grade Airway Inflammation and Increased Risk for COPD in Females

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2024 Feb 15

PMID 38357926

Authors

Irina Petrache

David Wh Riches

Affiliations

Soon will be listed here.

Abstract

Chronic low-grade inflammation is increasingly recognized as a subtle yet potent risk factor for a multitude of age-related disorders, including respiratory diseases, cardiovascular conditions, metabolic syndromes, autoimmunity, and cancer. In this issue of the JCI, Mebratu, Jones, and colleagues shed new light on the mechanisms that promote low-grade airway inflammation and how this contributes to the development of chronic obstructive pulmonary disease (COPD). Their finding that Bik deficiency leads to spontaneous emphysema in female mice, but not in males, marks a notable advancement in our understanding of how inflammatory processes can diverge based on biological sex. This finding is of clinical relevance, given the vulnerability of women to developing COPD.

References

Ferrucci L, Fabbri E . Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018; 15(9):505-522. PMC: 6146930. DOI: 10.1038/s41569-018-0064-2. View

Costanzo S, Magnacca S, Bonaccio M, Di Castelnuovo A, Piraino A, Cerletti C . Reduced pulmonary function, low-grade inflammation and increased risk of total and cardiovascular mortality in a general adult population: Prospective results from the Moli-sani study. Respir Med. 2021; 184:106441. DOI: 10.1016/j.rmed.2021.106441. View

Gan W, Paul Man S, Postma D, Camp P, Sin D . Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respir Res. 2006; 7:52. PMC: 1435894. DOI: 10.1186/1465-9921-7-52. View

Zhang X, Li D, Wang H, Pang C, Wu Y, Wen F . Gender difference in plasma fatty-acid-binding protein 4 levels in patients with chronic obstructive pulmonary disease. Biosci Rep. 2016; 36(1):e00302. PMC: 4770303. DOI: 10.1042/BSR20150281. View

Breyer M, Rutten E, Vernooy J, Spruit M, Dentener M, van der Kallen C . Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin. Respir Med. 2011; 105(7):1046-53. DOI: 10.1016/j.rmed.2011.02.001. View

Diaz A, Zhou L, Young T, McDonald M, Harmouche R, Ross J . Chest CT measures of muscle and adipose tissue in COPD: gender-based differences in content and in relationships with blood biomarkers. Acad Radiol. 2014; 21(10):1255-61. PMC: 4389286. DOI: 10.1016/j.acra.2014.05.013. View

Forsslund H, Yang M, Mikko M, Karimi R, Nyren S, Engvall B . Gender differences in the T-cell profiles of the airways in COPD patients associated with clinical phenotypes. Int J Chron Obstruct Pulmon Dis. 2017; 12:35-48. PMC: 5191844. DOI: 10.2147/COPD.S113625. View

Huang J, Wang L, Jiang M, Chen Q, Zhang X, Wang Y . Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384. Immunol Res. 2015; 64(2):461-9. DOI: 10.1007/s12026-015-8701-x. View

Arimura K, Aoshiba K, Tsuji T, Tamaoki J . Chronic low-grade systemic inflammation causes DNA damage in the lungs of mice. Lung. 2012; 190(6):613-20. DOI: 10.1007/s00408-012-9414-8. View

10.

Wielscher M, Mandaviya P, Kuehnel B, Joehanes R, Mustafa R, Robinson O . DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nat Commun. 2022; 13(1):2408. PMC: 9065016. DOI: 10.1038/s41467-022-29792-6. View

11.

Mebratu Y, Jones J, Liu C, Negasi Z, Rahman M, Rojas-Quintero J . Bik promotes proteasomal degradation to control low-grade inflammation. J Clin Invest. 2023; 134(4. PMC: 10866658. DOI: 10.1172/JCI170594. View

12.

Badrichani A, Stroka D, Bilbao G, Curiel D, Bach F, Ferran C . Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. J Clin Invest. 1999; 103(4):543-53. PMC: 408093. DOI: 10.1172/JCI2517. View

13.

Sun Y, Li Q, Zhang J, Chen Z, He Q, Liu X . Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis. Cell Signal. 2017; 36:34-41. DOI: 10.1016/j.cellsig.2017.04.005. View

14.

Mebratu Y, Schwalm K, Smith K, Schuyler M, Tesfaigzi Y . Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia. Am J Respir Crit Care Med. 2011; 183(11):1531-8. PMC: 3137142. DOI: 10.1164/rccm.201011-1930OC. View

15.

Han J, Sabbatini P, White E . Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol. 1996; 16(10):5857-64. PMC: 231587. DOI: 10.1128/MCB.16.10.5857. View

16.

Gut-Gobert C, Cavailles A, Dixmier A, Guillot S, Jouneau S, Leroyer C . Women and COPD: do we need more evidence?. Eur Respir Rev. 2019; 28(151). PMC: 9488562. DOI: 10.1183/16000617.0055-2018. View

17.

Levine B, Sinha S, Kroemer G . Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy. 2008; 4(5):600-6. PMC: 2749577. DOI: 10.4161/auto.6260. View