Low BIK Outside-inside-out Interactive Inflammation Immune-induced Transcription-dependent Apoptosis Through FUT3-PMM2-SQSTM1-SFN-ZNF384

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2015 Oct 2

PMID 26423071

Citations 3

Authors

Juxiang Huang

Lin Wang

Minghu Jiang

Qingchun Chen

Xiaoyu Zhang

Yangming Wang

Zhenfu Jiang

Zhongjie Zhang

Affiliations

Soon will be listed here.

Abstract

Eighteen different Pearson mutual-positive-correlation BIK-activatory molecular feedback upstream and downstream networks were constructed from 79 overlapping of 376 GRNInfer and 98 Pearson under BIK CC ≥ 0.25 in low normal adjacent tissues of Taiwan compared with high lung adenocarcinoma. Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), SQSTM1 (sequestosome 1), SFN_2 [REX2 RNA exonuclease 2 homolog (S. cerevisiae)] and ZNF384 (zinc finger protein 384) in low normal adjacent tissues of lung adenocarcinoma. BIK interactive total feedback terms included mitochondrial envelope, endomembrane system, integral to membrane, Golgi apparatus, cytoplasm, nucleus, cytosol, intracellular signaling cascade, mitochondrion, extracellular space, inflammation, immune response, apoptosis, cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in low normal adjacent tissues of lung adenocarcinoma. Therefore, we propose low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384 in normal adjacent tissues of lung adenocarcinoma.

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References

Zhou L, Wang H, Ren H, Chen D, Gao F, Hu Q . Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro. Acta Pharmacol Sin. 2013; 34(5):651-6. PMC: 3647217. DOI: 10.1038/aps.2013.12. View

Huang J, Wang L, Jiang M, Lin H, Qi L, Diao H . PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis. J Recept Signal Transduct Res. 2012; 32(5):250-6. DOI: 10.3109/10799893.2012.700717. View

Sun Y, Wang L, Jiang M, Huang J, Liu Z, Wolfl S . Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation. Cell Biochem Biophys. 2009; 56(2-3):59-71. DOI: 10.1007/s12013-009-9071-6. View

Huang J, Wang L, Jiang M, Chen Q, Jiang Z, Feng H . AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response. Cell Immunol. 2014; 290(1):102-6. DOI: 10.1016/j.cellimm.2014.05.008. View

Wang L, Huang J, Jiang M, Sun L . Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation. J Cell Biochem. 2011; 112(5):1286-94. DOI: 10.1002/jcb.23030. View

Huang J, Wang L, Jiang M . TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. J Inflamm (Lond). 2010; 7:50. PMC: 2959006. DOI: 10.1186/1476-9255-7-50. View

Wang L, Sun L, Huang J, Jiang M . Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation. Cell Prolif. 2011; 44(3):291-9. PMC: 6496776. DOI: 10.1111/j.1365-2184.2011.00752.x. View

Kawase T, Ichikawa H, Ohta T, Nozaki N, Tashiro F, Ohki R . p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Oncogene. 2008; 27(27):3797-810. DOI: 10.1038/onc.2008.32. View

Lin H, Wang L, Jiang M, Huang J, Qi L . P-glycoprotein (ABCB1) inhibited network of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum by systems-theoretical analysis. Cell Biochem Funct. 2012; 30(7):582-7. DOI: 10.1002/cbf.2837. View

10.

Jin Z, Zheng L, Xin X, Li Y, Hua T, Wu T . Upregulation of forkhead box O3 transcription is involved in C2-ceramide induced apoptosis and autophagy in ovarian cancer cells in vitro. Mol Med Rep. 2014; 10(6):3099-105. DOI: 10.3892/mmr.2014.2664. View

11.

Zhou Y, Liu Q, Liu C, Lin L . Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015; 36(7):5333-9. DOI: 10.1007/s13277-015-3194-8. View

12.

Wang L, Huang J, Jiang M, Lin H . Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunol Res. 2012; 52(3):258-68. DOI: 10.1007/s12026-012-8337-z. View

13.

Wang Y, Joshi T, Zhang X, Xu D, Chen L . Inferring gene regulatory networks from multiple microarray datasets. Bioinformatics. 2006; 22(19):2413-20. DOI: 10.1093/bioinformatics/btl396. View

14.

Wang L, Sun Y, Jiang M, Zhang S, Wolfl S . FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. Cancer Invest. 2009; 27(8):816-24. DOI: 10.1080/07357900802672753. View

15.

Wasim M, Mansha M, Kofler A, Awan A, Babar M, Kofler R . Promyelocytic leukemia zinc finger protein (PLZF) enhances glucocorticoid-induced apoptosis in leukemic cell line NALM6. Pak J Pharm Sci. 2012; 25(3):617-21. View

16.

Wang L, Huang J, Jiang M, Diao H, Zhou H, Li X . Cartilage oligomeric matrix protein (COMP)-mediated cell differentiation to proteolysis mechanism networks from human normal adjacent tissues to lung adenocarcinoma. Anal Cell Pathol (Amst). 2013; 36(3-4):93-105. PMC: 4605476. DOI: 10.3233/ACP-130084. View

17.

Meng X, Fraser M, Feller J, Ziegler J . Caspase-3 activates endo-exonuclease: further evidence for a role of the nuclease in apoptosis. Apoptosis. 2001; 5(3):243-54. DOI: 10.1023/a:1009604529237. View

18.

Wang L, Huang J, Jiang M, Lin H . Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation. J Mol Neurosci. 2012; 47(3):649-58. DOI: 10.1007/s12031-011-9702-4. View

19.

Wang L, Huang J, Jiang M, Lin H, Qi L, Diao H . Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection).... Integr Biol (Camb). 2012; 4(10):1256-62. DOI: 10.1039/c2ib20148h. View

20.

Akamatsu S, Yazawa S, Zenita K, Matsumoto H, Tachikawa T, Kannagi R . Elevation of an alpha(1,3)fucosyltransferase activity correlated with apoptosis in the human colon adenocarcinoma cell line, HT-29. Glycoconj J. 1996; 13(6):1021-9. DOI: 10.1007/BF01053198. View