Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Feb 1

PMID 38300528

Authors

Ignacio Campillo-Marcos

Marta Casado-Pelaez

Veronica Davalos

Gerardo Ferrer

Caterina Mata

Elisabetta Mereu

Gael Roue

David Valcarcel

Antonieta Molero

Lurdes Zamora

Blanca Xicoy

Laura Palomo

Pamela Acha

Ana Manzanares

Magnus Tobiasson

Eva Hellstrom-Lindberg

Francesc Sole

Manel Esteller

Affiliations

Soon will be listed here.

Abstract

Significance: MDS are myeloid clonal hemopathies with a low 5-year survival rate, and approximately half of the cases do not respond to standard HMA therapy. Our innovative single-cell multiomics approach offers valuable biological insights and potential biomarkers associated with the demethylating agent efficacy. It also identifies vulnerabilities that can be targeted using personalized combinations of small drugs and antibodies.

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