Association Between Dietary and Behavioral-based Oxidative Balance Score and Phenotypic Age Acceleration: a Cross-sectional Study of Americans

Overview

Journal Epidemiol Health

Specialty Public Health

Date 2024 Jan 25

PMID 38271958

Authors

Dongzhe Wu

Yulin Shen

Chaoyi Qu

Peng Huang

Xue Geng

Jianhong Zhang

Zhijian Rao

Qiangman Wei

Shijie Liu

Jiexiu Zhao

Affiliations

Soon will be listed here.

Abstract

Objectives: In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging.

Methods: Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis.

Results: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia.

Conclusions: A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.

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