Oxidants, Oxidative Stress and the Biology of Ageing

Overview

Journal Nature

Specialty Science

Date 2000 Nov 23

PMID 11089981

Citations 2639

Authors

T Finkel

N J Holbrook

Affiliations

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Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

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